SULT2B1 promotes cholangiocyte epithelial-mesenchymal transition via Wnt/β-catenin/MMP7 pathway in biliary atresia

EMT of cholangiocytes in BA is an important process in the development of biliary obstruction and liver fibrosis. SULT2B1 was a key molecule involved in regulating cholangiocyte EMT and liver fibrosis processes in BA. SULT2B1 induced by TGF-β1 up-regulated MMP7 and promoted EMT in Cholangiocytes. Blockage of the SULT2B1/Wnt/β-catenin/MMP7 axis may be a new therapeutic strategy to relieve BA liver fibrosis.