痴呆
医学
荟萃分析
认知
联想(心理学)
心血管健康
认知功能衰退
老年学
无症状的
内科学
心理学
精神科
疾病
心理治疗师
作者
Jing Wu,Ying Xiong,Xinhui Xia,Nicola Orsini,Chengxuan Qiu,Miia Kivipelto,Debora Rizzuto,Rui Wang
标识
DOI:10.1016/j.arr.2022.101788
摘要
This study aimed to quantify the relationships between the American Heart Association (AHA) Cardiovascular Health (CVH) metrics, namely AHA Life’s Simple 7, and cognitive outcomes. We searched PubMed and Embase (January 1, 2010—August 24, 2022) and finally included 14 longitudinal studies (311654 participants with 8006 incident dementia cases). Random-effects meta-analysis and one-stage linear mixed-effects models were performed. Increased CVH score seemed to associate with decreased risk of incident dementia in a linear manner, but this relationship varied by the measurement age of CVH metrics. That is, midlife CVH tended to have a linear association with late-life dementia risk, whereas a J-shaped association was observed between the late-life CVH score and dementia. In addition, late-life dementia risk was reduced significantly if individuals maintained an ideal level of AHA’s CVH guidelines of physical activity, fasting plasma glucose, total cholesterol, and smoking. However, our meta-analysis did not show a significant association between CVH score and global cognitive decline rate. Following AHA’s CVH guidelines and maintaining CVH at an optimal level would substantially reduce the late-life dementia risk. More research is required to explore the link between a favorable CVH score and cognitive trajectories among cognitively asymptomatic older populations.
科研通智能强力驱动
Strongly Powered by AbleSci AI