Infectious microenvironment responsive bimetallic sulfide combined with NIR irradiation to enhance photodynamic gas synergistic therapy of maxillofacial trauma

Abstract Maxillofacial trauma is an infection and oxidative stress‐induced damage to maxillofacial area related cells. Increasing evidences have suggested that therapeutic strategies with controllable anti‐infective and anti‐inflammatory capabilities hold great potentials in the clinical treatment of maxillofacial trauma. Herein, we reported an infectious microenvironment responsive bimetallic sulfide (FeCuS x , FCS) combining with near infrared (NIR) irradiation for maxillofacial trauma therapy. In cellular levels, FCS exhibited the most efficient antioxidant and anti‐inflammatory, cell migration, and angiogenesis behaviors through down‐regulating the inflammatory factor (iNOS) expression level, up‐regulating anti‐inflammatory factors (Arg‐1 and TGF‐β) expression level, inducing macrophages M2 polarization (CD86 down‐regulation and CD206 up‐regulation), and promoting tissue repair factors (CD31) expression level. Besides, it presented the excellent antibacterial ability of Escherichia coli (99.74%) and MRSA (99.78%) for FCS + NIR. Significantly, it also confirmed that FCS + NIR presented the excellent functions of inhibiting wound infections, decreasing wound inflammation, as well as promoting trauma tissue repairing. Altogether, it had developed the strategy of FCS + NIR for the synergistic enhancement of infectious maxillofacial trauma healing, could also serve as a promising therapeutic strategy for the treatment of infectious diseases.