Asymmetric 1,4‐Addition and Functionalization Strategy in Total Synthesis

The transition‐metal catalyzed enantioselective 1,4‐addition and subsequent functionalization strategy provides a powerful approach to construct 2,3‐disubstituted cycloalkanones, which are further utilized as important intermediates in the total synthesis of natural products. This concept article highlights recent advances in the methodology development and related synthetic application.