Profiling of Diagnostic Value of Serum CysC, β2‐MG and α‐Klotho in Early Acute Kidney Injury Caused by Acute Myocardial Infarction

OBJECTIVE: To decipher the diagnostic value of serum cystatin C (CysC), β2-microglobulin (β2-MG) and α-Klotho in early acute kidney injury (AKI) caused by acute myocardial infarction (AMI). METHODS: This study screened 176 eligible patients and established two groups of AKI group (n = 51) and non-AKI group (n = 125). This study measured and compared the serum CysC, β2-MG, α-Klotho, serum creatinine (Scr), blood urea nitrogen (BUN), creatine kinase isoenzymes MB (CK-MB) and cardiac troponin T (cTnI) between the two groups. This study further analyzed correlations of CysC, β2-MG and α-Klotho with Scr and BUN, and the relationship of various indicators with AKI, with receiver operating characteristic (ROC) curves plotted. RESULTS: AKI group was detected with significant changes in baseline data compared with non-AKI group. Serum CysC, β2-MG and α-Klotho had significantly positive correlations with Scr and BUN. CK-MB, Scr, BUN, CysC, β2-MG, and α-Klotho were independent risk factors for AKI in AMI patients. The AUC, sensitivity, and specificity of CysC for predicting AKI were 0.840, 0.627, and 0.984; which were 0.835, 0.784, and 0.864 for β2-MG; 0.881, 0.824, and 0.832 for α-Klotho; as well as 0.913, 0.843, and 0.880 when using three indicators jointly. Joint detection had better predictive performance for AKI than any single indicator. CONCLUSION: Serum CysC, β2-MG and α-Klotho are significantly positively correlated with reduced renal function and are independent risk factors for AKI, exhibiting high early diagnostic value for AKI in AMI patients.