Mucoadhesive-to-Mucopenetrating Nanoparticles for Mucosal Drug Delivery: A Mini Review

Mucosal tissue acts as a barrier between the human body's internal environment and the external world. The mucosal tissue is shielded from injurious environmental chemicals, toxins, and pathogens by a mucus layer lining above the mucosal tissue, and meanwhile the periodic mucosal clearance accelerates the removal of mucoadhesive components. And therefore, transmucosal drug delivery is limited. Nanocarriers for mucosal drug delivery is recently developed to enhance either long retention of drugs within the mucus layer or rapid translocation of drugs across the mucus layer. Among all these types of drug delivery systems, mucoadhesive-to-mucopenetrating nanocarriers transport drugs most efficiently into targeted mucosal tissues. In this review, recent progress on the mucoadhesive-to-mucopenetrating drug delivery systems and their application are updated.