硼胆酸
医学
熊去氧胆酸
原发性胆汁性肝硬化
贝扎纤维
胃肠病学
内科学
受体
兴奋剂
作者
Chung-Heng Liu,Christopher L. Bowlus
标识
DOI:10.1016/j.cld.2022.06.012
摘要
Primary biliary cholangitis (PBC) is an autoimmune disease of the interlobular bile ducts leading to secondary damage of hepatocytes and may progress to cirrhosis and liver failure. The first-line treatment is ursodeoxycholic acid; up to 40% of patients do not have an adequate response and remain at risk of disease progression. Obeticholic acid has been conditionally approved for the treatment of PBC as add-on therapy and bezafibrate has shown similar efficacy in this group of patients. Several new therapies are in development and may further add to the treatment options available to patients with PBC.
科研通智能强力驱动
Strongly Powered by AbleSci AI