SPACEFLIGHT EFFECTS ON GLIAL CELLS OF MOUSE BONE MARROW

Immunohistochmistrry was used to analyze lumbar enlarements in C57BL/76N mice on day 30 of a space flight with and w/o 7 day deadaptation to Earth. Space flown and non-deadpted mice had a increased number of S100B+ -cells in the cental channel zone and decreased population of GFAP astrocytes in ventral horns, Olig2+ cells in the corticospinal tract, PO+ -cells in vental horns and dorsal roots entry zone and Krox24+ -cells in ventral horns, dorsal roots entry zone and central channel zone, and reduced OSP fluorescence density in ventral channels. Elevated expression of myelin-producing Olig2, PO and Krox24 markers on day 7 of deadaptation implies recovery, significance of immunocytochemical changes in the myelin-producing cells in space flight, and suggests portentially rapid normalization of pathologic deviations in myelin fibers in consequence of sthe hypogravity motor syndrome.