The influence of processing parameters of steel casting, hot working and heat treatment on strength and toughness of quenched and tempered steel and cast steel was investigated. Strength was presented by yield strength, while toughness was presented by Charpy-V notch toughness. Experimental procedure was done using the 25-2 factor experiment. It was found out that yield strength is insensitive on differences between applied manufacturing processes, but by application of hot working and with proper pouring temperature the Charpy-V notch toughness is increased. Also, Charpy-V notch toughness is increased by interactive effect of the proper cooling rate during the casting and hot working. Mathematical expressions for prediction of yield strength and Charpy-V notch toughness of steel and cast steel were established. Established mathematical expressions were applied in computer simulation of mechanical properties of shafts made of steel and cast steel.