CD80
CD86
免疫系统
一氧化氮
细胞生物学
脂质体
化学
树突状细胞
多糖
巨噬细胞
分泌物
吞噬作用
抗原
生物
T细胞
免疫学
CD40
细胞毒性T细胞
生物化学
体外
有机化学
作者
Weiyang Zhang,Wuren Ma,Jing Zhang,Xiaoping Song,Wenjing Sun
标识
DOI:10.1016/j.ijbiomac.2017.07.108
摘要
The objective of this study is to investigate the immunomodulatory activities of astragalus polysaccharide liposome (APSL) on murine peritoneal macrophages and bone marrow derived dendritic cells (DCs). The results showed that APSL not only significantly improved the phagocytosis of macrophages, the contents of IL-6 and IL-12, and the secretion of nitric oxide (NO) and inducible nitric oxide synthase (iNOS) in macrophages, but also promoted the proliferation of DCs precursor cells, enhanced the abilities of DCs on stimulating T-cell proliferation and presenting antigen, upregulated IFN-γ and IL-2 production of DCs, and improved the expression of CD80 and CD86 in DCs compared with astragalus polysaccharide (APS). These findings indicated that the immune-modulating activities of APS were remarkably enhanced after encapsulated with liposome, and liposome possessed the potential to act as effective drug delivery system. Moreover, it also provided the theoretical basis for further researching the mechanism of APSL on improving the immune response.
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