生物累积
舍曲林
药品和个人护理产品的环境影响
生物浓缩
环境化学
西酞普兰
化学
药理学
米氮平
流出物
环境科学
抗抑郁药
生物
医学
血清素
内科学
环境工程
海马体
受体
生物化学
作者
Kateřina Grabicová,Roman Grabic,Ganna Fedorová,Jerker Fick,Daniel Červený,Jitka Kolářová,Jan Turek,Vladimír Žlábek,Tomáš Randák
出处
期刊:Water Research
[Elsevier]
日期:2017-11-01
卷期号:124: 654-662
被引量:144
标识
DOI:10.1016/j.watres.2017.08.018
摘要
The treated effluent from sewage treatment plants (STP) is a major source of active pharmaceutical ingredients (APIs) that enter the aquatic environment. Bioaccumulation of 11 selected psychoactive pharmaceuticals (citalopram, clomipramine, haloperidol, hydroxyzine, levomepromazine, mianserin, mirtazapine, paroxetine, sertraline, tramadol and venlafaxine) was examined in Zivny Stream (tributary of the Blanice River, the Czech Republic), which is a small stream highly affected by effluent from the Prachatice STP. Six of the 11 pharmaceuticals were detected in grab water samples and in passive samplers. All pharmaceuticals were found in fish exposed to the stream for a defined time. The organs with highest presence of the selected pharmaceuticals were the liver and kidney; whereas only one pharmaceutical (sertraline) was detected in the brain of exposed fish. Fish plasma and muscle samples were not adequate in revealing exposure because the number of hits was much lower than that in the liver or kidney. Using the criterion of a bioaccumulation factor (BAF) ≥ 500, citalopram, mianserin, mirtazapine and sertraline could be classified as potential bioaccumulative compounds. In combination, data from integrative passive samplers and fish liver or kidney tissue samples were complimentary in detection of target compounds and simultaneously helped to distinguish between bioconcentration and bioaccumulation.
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