Lipid Accumulation Product and Sarcopenia in Korean Patients with Type 2 Diabetes

Lipid accumulation product (LAP), a new biomarker for lipid over accumulation in adults. has been suggested to show better relationships with insulin resistance (IR), metabolic syndrome (MS), and type 2 diabetes, and cardiovascular disease (CVD) than body mass index (BMI). Sarcopenia is proposed to risk factor for IR, MS, type 2 diabetes, and CVD. However, association between LAP and sarcopenia is not approved yet. We evaluated relationship between LAP and sarcopenia in patients with type 2 diabetes. Total of 481 subjects with type 2 diabetes were enrolled. LAP was estimated as follows: [waist circumference (WC)-65] X [triglycerides (TG)] in men and [WC-58] X [TG] in women. Appendicular skeletal muscle mass (ASM) was measured using dual energy X-ray absorptiometry (DEXA). Sarcopenia was defined as follows: ASM/ BMI<0.789 in men and <0.521 in women. Patients with the highest tertile of LAP were more likely to be hypertensive and current drinkers and less likely to have regular exercise than those with the lowest. They had higher values of BMI, systolic and diastolic blood pressure (BP), total cholesterol, HOMA-IR, and liver enzymes and lower values of age, HDL, and vitamin D3 (vitD3). Sarcopenic subjects gradually increased with increasing tertiles of LAP (p<0.05). Odds ratios (ORs) in the highest tertile of LAP for sarcopenia after adjusted for age and gender were 1.884 (95% CI=1.128-3.146, p=0.015) in 2nd tertiles and 2.784 (95% CI=1.641-4.724, p<0.001) in the highest. The association between LAP and sarcopenia remained significant after further adjustments for hypertension, currents drinking, regular exercise, total cholesterol, HDL, HOMA-IR, CRP, vitD3, and liver enzymes. LAP was significantly associated with sarcopenia in patients with type 2 diabetes independent of age, gender, hypertension, current drinking, regular exercise, BP, total cholesterol, HDL, HOMA-IR, CRP, vitD3, and liver enzymes. Further studies are required to investigate a causal relationship between LAP and sarcopenia. Disclosure J. Shin: None.