核酸
硅氢加成
硅烷化
双功能
化学
表面改性
荧光
核酸热力学
组合化学
有机化学
生物化学
催化作用
DNA
基序列
物理化学
物理
量子力学
作者
Krzysztof Kuciński,Magdalena Jankowska‐Wajda,Tomasz Ratajczak,Sandra Bałabańska-Trybuś,Anna Schulmann,Hieronim Maciejewski,Marcin K. Chmielewski,Grzegorz Hreczycho
出处
期刊:ACS omega
[American Chemical Society]
日期:2018-06-01
卷期号:3 (6): 5931-5937
被引量:5
标识
DOI:10.1021/acsomega.8b00547
摘要
In this paper, the Pt-catalyzed hydrosilylation of hydroxyl ethers is described. Various bifunctional alkoxysilanes were obtained and applied in O-silylation of free hydroxyl groups on the silica surface. These modified solid materials have been used as excellent supports for linking synthetic nucleic acids. Nucleic acids permanently attached to the solid surface were tested in hybridization with complementary fluorescence-labeled sequences. Detection of nucleic acids anchored to the solid support was performed by fluorescence microscopy after hybridization.
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