罗丹明6G
等离子体子
材料科学
纳米棒
纳米技术
皮肤贴
表面增强拉曼光谱
间质液
拉曼散射
拉曼光谱
生物医学工程
分子
化学
光电子学
光学
病理
有机化学
物理
医学
作者
Chandana Kolluru,Rohit Gupta,Qisheng Jiang,Mikayla Williams,Hamed Gholami Derami,Sisi Cao,Richard K. Noel,Srikanth Singamaneni,Mark R. Prausnitz
出处
期刊:ACS Sensors
[American Chemical Society]
日期:2019-05-09
卷期号:4 (6): 1569-1576
被引量:46
标识
DOI:10.1021/acssensors.9b00258
摘要
Minimally invasive devices to detect molecules in dermal interstitial fluid (ISF) are desirable for point-of-care diagnostic and monitoring applications. In this study, we developed a microneedle (MN) patch that collects ISF for on-patch biomarker analysis by surface-enhanced Raman scattering (SERS). The micrometer-scale MNs create micropores in the skin surface, through which microliter quantities of ISF are collected onto plasmonic paper on the patch backing. The plasmonic paper was prepared by immobilizing poly(styrenesulfonate) (PSS) coated gold nanorods (AuNRs) on a thin strip of filter paper using plasmonic calligraphy. Negatively charged PSS was used to bind positively charged rhodamine 6G (R6G), which served as a model compound, and thereby localize R6G on AuNR surface. R6G bound on the AuNR surface was detected and quantified by acquiring SERS spectra from the plasmonic paper MN patch. This approach was used to measure pharmacokinetic profiles of R6G in ISF and serum from rats in vivo. This proof-of-concept study indicates that a plasmonic paper MN patch has the potential to enable on-patch measurement of molecules in ISF for research and future medical applications.
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