Directed interactions of heterotrimeric G‐proteins coupled to receptors responding to extracellular signals and small Ras‐related GTPases that control a variety of intracellular processes are being elucidated by recent work. We explore two of the most well‐characterized pathways that couple big G‐proteins to their smaller relatives.—Bokoch, G. M. Interplay between Ras‐related and heterotrimeric GTP binding proteins: lifestyles of the big and little. FASEB J. 10, 1290‐1295(1996)