Comparative study of pancreatic fat content between newly-diagnosed patients with type 2 diabetes and healthy volunteers by chemical shift magnetic resonance imaging

Objective: To compare pancreatic fat content between newly-diagnosed patients with type 2 diabetes and healthy volunteers by chemical shift MRI,and explore their correlations with hepatic fat content. Materials and Methods: Seventy patients with newly-diagnosed type 2 diabetes and BMI、gender and age matched 31 healthy volunteers were recruited in this study. Fat content in the pancreas and liver was respectively measured,calculated,and compared with the sequence of double-echo chemical shift gradient-echo magnetic resonance imaging. The correlation between liver and pancreatic fat content was analyzed. Results: The average fat content of the liver and pancreas in patients with newly-diagnosed type 2 diabetes were higher than that in the healthy volunteers. Hepatic and pancreatic fat fraction were 9.87%±3.19% and 7.24%±2.38%(t=-4.56,P0.05),as well as 5.15%±3.75% and 3.48%±1.97%(t=-3.01,P0.05),respectively,in the two groups,and statistically significant differences among them were obvious. Correlation coefficients in the two samples of liver and pancreatic fat content were 0.053(P0.05) and 0.337(P0.05),both of them were not correlated each other. Conclusions: Hepatic and pancreatic fat content in newly-diagnosed patients with type 2 diabetes were higher than that of healthy volunteers,and the pancreatic and hepatic fat content were not correlated in the two groups.