OBJECTIVE: To find out the optimum extraction process for total salvianolic acid part of radix Salviae miltiorrhizae. METHOD: The extraction process was studied by orthogonal design with the danshen su content determined by RP-HPLC as index. RESULT: A3B3C2D1 is the best extraction condition of aqueous part from radix Salvia miltiorrhiza. CONCLUSION: This extraction process shows total salvianolic acid has high content and good stability.