[Prescription design and dissolution evaluation of self-emulsifying drug delivery systems of baicalin]

Objective To improve dissolution and bioavailability of baicalin in solid prescription and screen the prescription of self-emulsifying drug delivery systems of baicalin. Methods Orthogonal test was applied to optimize the prescription of self-emulsifying drug delivery systems of baicalin, and the best prescription was selected by comprehensive evaluation of emulsion speed, size and light transmission rate. Results The best quantity ratio of self-emulsifying drug delivery systems of baicalin was baicalin: polysorbate 80: oliver oil: glycerol = 0.15 : 1 : 1 : 1.5. Conclusion Self-emulsifying drug delivery systems of baicalin prepared can effectively improve the dissolution of baicalin in artificial gastric juice.