Study on the safety and efficacy of three amino salicylc acid preparations for treating ulcerative colitis

Objective To evaluate the therapeutic effects of mesalazine, osalazine and sulfasalazine for patientswith ulcerative colitis. Methods 120 patients with ulcerative colitis were randomly divided into mesalazinegroup(n=40), osalazine group(n=39) and sulfasalazine group(n=41). The efficacy and adverse events of the three groups were observed after the treatment of 12 weeks. Results The rate of complete remission and overall effective rate of three groupswere30.0%, 28.2% and 51.2%; 75.0%, 76.9% and 92.7%, respectively. And the differences between mesalazine/osalazine and sulfasalazine were statistically significant(P 0.05). Conclusion Compared with mesalazine and osalazine, sulfasalazine is more effective in treatment of ulcerative colitis, but with a relatively higher incidence of adverse reactions.