Protective effect of Redix astragail on intestinal mucosa barrier and intestinal mucosa apoptosis in infant rabbits with ischemia-reperfusion

Objectives To study the protective effect of Redix astragail on intestinal mucosa barrier and intestinal mucosa apoptosis in infant rabbits with ischemia-reperfusion. Methods Twenty male infant rabbits were divided into 4 groups randomly:sham control group,model group,Redix astragail group and control group. Redix astragail group and control group were injected with Redix astragail 6 mg/(kg·d) or sodium chloride 7 days before operation,respectively. SOD activity of intestinal mucosa and plasma,intestinal mucosa apoptosis index and degree of injury to intestinal mucosa tissue were observed in infant rabbits with ischemia-reperfusion. The influences of Redix astragail on them were also stu- died. Results After ischemia-reperfusion,SOD activity in intestinal mucosa and plasma decreased obviously,but intestinal mucosa apoptosis index,intestinal mucosa tissue morphology and intestinal mucosa barrier lesion increased. Redix Astragail could significantly improve the above changes. Conclusions Redix astragail played an important role in protection of intestine mucosa barrier of infant rabbits with ischemia-reperfusion.