Objective:To observe the relationship between second stage of labor and cephalopelvic disproportion.Methods:276 cases were divided into cephalopelvic disproportion group(56 cases) and abnormal second stage of labor group(220 cases).Results:83 cases underwent cesarean section,including 56 cases in cephalopelvic disproportion group,accounting for 67.47%;body weight greater than 4 000 g was 33 cases,including 13 cases in cephalopelvic disproportion group,accounting for 39.4%;the amount of soft birth canal laceration,postpartum hemorrhage,puerperal infection and poor wound healing was 83 cases,including 37 cases in cephalopelvic disproportion group,accounting for 44.58%.Conclusion:Cephalopelvic disproportion is the cause of abnormal second stage of labor and a vital effect factor of cesarean section and maternal adverse reactions,proper treatment of cephalopelvic disproportion may reduce the incidence of abnormal second stage of labor and risk of mothers and infants.