Advance in Connexin and brain edema

Connexin are the basic structure and function protein of gap junction. About 20 connexin have been found in the mammals' tissues and organs so far. Cx43 is the most abundant protein in the gap junction protein, mainly exist in astrocytes. Cx43 plays an very important role in the communication of gap junction mediated by GJ. At present, About the Cx43's research is mainly concentrated in tumor, cardiovascular, epilepsy, cerebral edema, etc. This review presents a research progress between Cx43 and brain edema.