Objective To understand the prevalence of metabolic syndrome(MS) and fatty liver in different gender and age employees from the firms in Zhangyan Town Jinshan District of Shanghai and investigate the association between the metabolic syndrome and the fatty liver.Methods The medical data of 10,437 employees were collected.The chi-square test was used to compare the differences in prevalence between MS and fatty liver.The multivariable stepwise logistic regression analysis was used to analyze the risk factors of fatty liver,and compare the different indicators of prevalence odds ratio(Odds ratio,OR) in fat liver group and the non-fatty liver group.Results The prevalence of metabolic syndrome and fatty liver increased with the age,and the incidence of MS and fatty liver in male were higher than those in female(P0.001);In addition to dyslipidemia,the incidences of other diseases in the group with service period over 20 years were higher than those in the group with the service period less than 10 years and between 11 and 20 years.Conclusion The prevalence of MS and fatty liver is high;MS and fatty liver are closely related.Fatty liver can be observed as the components of MS,and the early screening of the fatty liver can contribute to detecting the MS.This study can also provide a theoretical basis to the correlation of the fatty liver and the MS.