Study of hypercoagulation state in patients with atrial fibrillation

Objective To investigate the hypercoagulation state markers in patients with atrial fibrillation and their clinical significance.Methods Sixty patients with chronic atrial fibrillation were divided into two groups,one group having no heart failure(group one,n=30) and the other having heart failure(group two,n=30).There were two age-matched and sex-matched control groups,the normal sinus rhythm group including 40 patients with cardiovascular disease but in sinus rhythm and normal heart function, the health control group including 33 healthy subjects.The plasma fibrin D-dimer was assayed using enzyme linked immunoassay.Fibrinogen(Fg) was measured.Results Compared with the healthy control group and the normal sinus rhythm group,patients with atrial fibrillation(group one) had significant increase of fibrin D-dimer(474.5) μg/L((220.0)-(843.9) μg/L) and Fg((3.74)±(0.76)) g/L,patients with atrial fibrillation and heart failure(group two) had significant increase of fibrin Ddimer(657.9) μg/L((365.8)-(1448.6) μg/L) and Fg((4.25)±(0.95)) g/L,(P(0.05)).Plasma Fg and D-dimer level were higher in group two than that in group one,(P(0.05)).In atrial fibrillation patients with left atrial diameter≥40 mm,Plasma Fg and(D-dimer) level were higher than those with left atrial diameter40 mm(P(0.05)).Conclusion Patients with atrial fibrillation show evidence of hypercoagulation,which may be correlated with the atrial thrombogenesis.In patients with atrial fibrillation,heart failure and left atrial diameter effect the levels of plasma Ddimer and Fg.