重编程
缺氧(环境)
调节器
氧气
癌细胞
生物
化学
细胞生物学
缺氧诱导因子
表型
癌症
氧代谢
细胞代谢
细胞
新陈代谢
癌症研究
生物化学
作者
Hong Xie,M. Celeste Simon
标识
DOI:10.1074/jbc.r117.799973
摘要
Hypoxia and dysregulated metabolism are defining features of solid tumors. How cancer cells adapt to low O2 has been illuminated by numerous studies, with reprogrammed metabolism being one of the most important mechanisms. This metabolic reprogramming not only promotes cancer cell plasticity, but also provides novel insights for treatment strategies. As the most studied O2 sensor, hypoxia-inducible factor (HIF) is regarded as an important regulator of hypoxia-induced transcriptional responses. This minireview will summarize our current understanding of hypoxia-induced changes in cancer cell metabolism, with an initial focus on HIF-mediated effects, and will highlight how these metabolic alterations affect malignant phenotypes.
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