实验性自身免疫性脑脊髓炎
20立方厘米
中央控制室4
C-C趋化因子受体6型
髓鞘少突胶质细胞糖蛋白
脑脊髓炎
趋化因子
CCL22型
免疫学
医学
药理学
受体
多发性硬化
趋化因子受体
内科学
作者
Abdollah Jafarzadeh,Zahra Arabi,Rayhaneh Ahangar-Parvin,Marziyeh Mohammadi-Kordkhayli,Maryam Nemati
出处
期刊:Drug research
[Georg Thieme Verlag KG]
日期:2017-07-03
卷期号:67 (11): 632-639
被引量:21
标识
DOI:10.1055/s-0043-113455
摘要
Abstract Background Chemokines facilitate the leukocytes infiltration into the central nervous system (CNS) which is an essential step in the pathogenesis of multiple sclerosis. Ginger has also a broad anti-inflammatory properties. The aim was to evaluate the effects of ginger extract on the expression of CCL20 and CCL22 and their receptors (CCR6 and CCR4, respectively) in experimental autoimmune encephalomyelitis (EAE). Material and Methods Female C57BL/6 mice used for EAE induction by immunization with myelin oligodendroglial glycoprotein. Then, the EAE mice were treated with PBS or ginger extract, from day +3 to +30. At day 31, mice were scarified and the expression of CCL20 and CCL22 and their receptors in the spinal cord measured using real time-PCR. Results The expression of CCL20, CCL22 and CCR4 in the spinal cord of PBS-administrated EAE mice was significantly higher than healthy group (P<0.04, P<0.05 and P<0.02, respectively). In 200- and 300 mg/kg ginger extract-treated EAE mice, the expression of CCL20, CCL22 and CCR4 were significantly reduced as compared with PBS-administrated EAE group (P<0.04, P<0.01 and P<0.002 for 200 mg/kg ginger extract and P<0.01, P<0.005 and P<0.004 for 300 mg/kg ginger extract, respectively). The CCR6 expression in EAE mice treated with 200- or 300 mg/kg ginger extracts was lower than PBS-administrated EAE mice (P<0.01 and P=0.07, respectively). Conclusion Treatment of EAE mice with ginger extract down-regulate the expression of CCL20 and CCL22 and their receptors in EAE mice. The possible therapeutic potential of ginger for treatment of MS can be considered in future investigations.
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