血管生成
糖酵解
新陈代谢
癌症研究
癌细胞
脂肪酸代谢
癌症治疗
脂肪酸
生物化学
脂肪酸合成
癌症
化学
生物
细胞生物学
生物信息学
遗传学
作者
Ulrike Harjes,Joanna Kalucka,Peter Carmeliet
标识
DOI:10.1016/j.critrevonc.2015.10.011
摘要
Tumour angiogenesis has long been recognised as a target for anti-cancer therapy. The current approach of inhibiting the VEGF pathway has shown benefit in the clinic, though less than anticipated. We recently documented that glycolytic metabolism in endothelial cells (ECs) fuels angiogenesis, rendering it a possible target for inhibiting vascular growth in pathological conditions. More recently, we reported that the oxidation of fatty acids (FA) is irreplaceable for EC proliferation by providing carbons for de novo nucleotide synthesis. Furthermore, ECs are rather unique in this respect, creating novel therapeutic opportunities. Here, we review and compare the current understanding of FA utilisation in ECs and tumour cells (TCs).
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