Effects of Pueraria lobata/Rehmannia glutinosa combination with exercise on metabolic changes in ovariectomized rats (702.6)

There is a fair amount of evidence showing that increased risks of obesity and insulin resistance are associated with postmenopausal state, but can be modulated by diet and exercise. In this study, we evaluated the effects of Pueraria lobata/Rehmannia glutinosa combination (PR), exercise, or both on metabolic changes in ovariectomized (OVX) Sprague Dawley rats for 8 weeks: Sham control, OVX control, OVX+PR (200 and 400 mg/kg bw), OVX+EX, OVX+EX+PR (200 and 400 mg/kg bw) ( n =10/group). PR was fed by gavage and incremental treadmill exercise was used. Oral glucose tolerance test was measured at week 4 and week 8. After 8 weeks, fasting plasma levels of glucose, insulin, C‐peptide, total cholesterol, free fatty acids, leptin, and adiponectin were measured. mRNA expressions (Glut 4 and FOXO) and western blotting (p‐IRS and p‐AKT) were also studied in the muscle. Together, the results suggest the additive effects of PR supplementation and exercise in the management of postmenopausal metabolic changes. Grant Funding Source : This research was supported by MOTIE/KIAT (N0000697) and MEST/BK 21 PLUS (22A20130012143).