脱氢酶
ATP柠檬酸裂解酶
脂肪酸合成
生物化学
支链α-酮酸脱氢酶复合物
脂肪酸合酶
甘油
柠檬酸循环
酶
化学
甘油-3-磷酸脱氢酶
柠檬酸合酶
生物
作者
Jacek Turyn,Beata Schlichtholz,Agnieszka Dettlaff-Pokora,Malgorzata Presler,Elżbieta Goyke,Marcin Matuszewski,Zbigniew Kmieć,K Krajka,Julian Świerczyński
出处
期刊:Hormone and Metabolic Research
[Georg Thieme Verlag KG]
日期:2003-11-07
卷期号:35 (10): 565-569
被引量:77
摘要
Common molecular changes in cancer cells are high carbon flux through the glycolytic pathway and overexpression of fatty acid synthase, a key lipogenic enzyme. Since glycerol 3-phosphate dehydrogenase creates a link between carbohydrates and the lipid metabolism, we have investigated the activity of glycerol 3-phosphate dehydrogenase and various lipogenic enzymes in human bladder cancer. The data presented in this paper indicate that glycerol 3-phosphate dehydrogenase activity in human bladder cancer is significantly higher compared to adjacent non-neoplastic tissue, serving as normal control bladder tissue. Increased glycerol 3-phosphate dehydrogenase activity is accompanied by increased enzyme activity, either directly (fatty acid synthase) or indirectly (through ATP-citrate lyase, glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and citrate synthase) involved in fatty acid synthesis. Coordinated upregulation of glycerol 3-phosphate dehydrogenase and lipogenic enzymes activities in human bladder cancer suggests that glycerol 3-phosphate dehydrogenase supplies glycerol 3-phosphate for lipid biosynthesis.
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