协同运输机
共转运蛋白
分泌物
运输机
基因亚型
离子运输机
吸收(声学)
胃肠道
细胞生物学
ATP酶
突变体
钠氢反转运蛋白
化学
离子通道
生物
生物化学
基因
膜
酶
钠
材料科学
受体
复合材料
有机化学
作者
Gary E. Shull,Marian L. Miller,Patrick J. Schultheis
出处
期刊:American Journal of Physiology-gastrointestinal and Liver Physiology
[American Physiological Society]
日期:2000-02-01
卷期号:278 (2): G185-G190
被引量:30
标识
DOI:10.1152/ajpgi.2000.278.2.g185
摘要
Absorption and secretion of ions in gastrointestinal and other epithelial tissues require the concerted activities of ion pumps, channels, symporters, and exchangers, which operate in coupled systems to mediate transepithelial transport. Our understanding of the identities, membrane locations, and biochemical activities of epithelial ion transporters has advanced significantly in recent years, but major gaps and uncertainties remain in our understanding of their physiological functions. Increasingly, this problem is being addressed by the analysis of mutant mouse models developed by gene targeting. In this review, we discuss gene knockout studies of the secretory isoform of the Na(+)-K(+)-2Cl(-) cotransporter, isoforms 1, 2, and 3 of the Na(+)/H(+) exchanger, and the colonic H(+)-K(+)-ATPase. This approach is leading to a clearer understanding of the functions of these transporters in the living animal.
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