Histopathology and molecular pathology are two important branches of human pathology, which provide a bridge between clinical and basic medicine. As a basic discipline of clinical pathology, histopathology is the basic morphology for the study of pathogenesis. As a developing discipline, molecular pathology has gradually penetrated the entire process of clinical management. Digital pathology based on artificial intelligence has prompted the deep integration of histopathology, molecular pathology and clinical information to enrich the mission of pathology. Clinical pathologists should integrate histopathology and molecular pathology to accurately practise personalized medicine by new technologies and methods.