血栓
抗血栓
医学
血栓形成
血小板
冲程(发动机)
缺血性中风
血小板活化
心脏病学
缺血
内科学
免疫学
机械工程
工程类
作者
Rentang Bi,Shengcai Chen,Shaolin Chen,Qiwei Peng,Huijuan Jin,Bo Hu
标识
DOI:10.1007/s00018-021-03897-5
摘要
Ischemic stroke is one of the most serious diseases today, and only a minority of patients are provided with effective clinical treatment. Importantly, leukocytes have gradually been discovered to play vital roles in stroke thrombosis, including promoting the activation of thrombin and the adhesion and aggregation of platelets. However, they have not received enough attention in the field of acute ischemic stroke. It is possible that we could not only prevent stroke-related thrombosis by inhibiting leukocyte activation, but also target leukocyte components to dissolve thrombi in the cerebral artery. In this review, we expound the mechanisms by which leukocytes are activated and participate in the formation of stroke thrombus, then describe the histopathology of leukocytes in thrombi of stroke patients and the influence of leukocyte composition on vascular recanalization effects and patient prognosis. Finally, we discuss the relevant antithrombotic strategies targeting leukocytes.
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