斑秃
脱发
毛囊
间充质干细胞
体内
医学
炎症
免疫学
内科学
内分泌学
病理
生物
皮肤病科
生物技术
作者
Weiyue Deng,Yuying Zhang,Wei Wang,Aishi Song,Omar Mukama,Jingmin Huang,Xiaobo Han,Simin Deng,Zuoxian Lin,Jean du Dieu Habimana,Rongqi Huang,Kexin Peng,Bing Ni,Shusheng Zhang,Xiao‐Xin Yan,Ji Li,Lin Wu,Zhiyuan Li
标识
DOI:10.1186/s13287-021-02614-0
摘要
Alopecia areata (AA) is a common autoimmune hair loss disease with increasing incidence. Corticosteroids are the most widely used for hair loss treatment; however, long-term usage of hormonal drugs is associated with various side effects. Mesenchymal stem cells (MSCs) therapy has been studied extensively to curb autoimmune diseases without affecting immunity against diseases.Hair follicle-derived MSCs (HF-MSCs) were harvested from the waste material of hair transplants, isolated and expanded. The therapeutic effect of HF-MSCs for AA treatment was investigated in vitro AA-like hair follicle organ model and in vivo C3H/HeJ AA mice model.AA-like hair follicle organ in vitro model was successfully established by pre-treatment of mouse vibrissa follicles by interferon-γ (IFN-γ). The AA-like symptoms were relieved when IFN-γ induced AA in vitro model was co-cultured with HF-MSC for 2 days. In addition, when skin grafted C3H/HeJ AA mice models were injected with 106 HF-MSCs once a week for 3 weeks, the transcription profiling and immunofluorescence analysis depicted that HF-MSCs treatment significantly decreased mouse hair loss and reduced inflammation around HF both in vitro and in vivo.This study provides a new therapeutic approach for alopecia areata based on HF-MSCs toward its future clinical application.
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