Photoredox-Mediated Desulfonylative Radical Reactions: An Excellent Approach Towards C–C and C–Heteroatom Bond Formation

Abstract In recent times, desulfonylative radical-cross-coupling (RCC) has come to the forefront in synthetic organic, bio, and material chemistry as a powerful strategy to form C–C and C–heteroatom bonds. Diverse functionalization through metal- and photoredox-catalyzed desulfonylation reactions has attracted the scientific community due to the mild reaction conditions, wide functional group tolerance, and excellent synthetic efficacy. In this review, we have highlighted photoredox-mediated desulfonylation reactions developed since 2000. This review will summarize the newly reported methodologies, with particular emphasis on their mechanistic aspects and selectivity issues which have paved a new way towards sustainable C–C and C–X (X = H or heteroatom) bond formation. 1 Introduction 2 Photoredox-Catalyzed C–C Bond Formation 2.1 Aryl Sulfones as Radical Precursor 2.2 Reactions of Allyl Sulfones 3 Photoredox-Catalyzed C–Heteroatom Bond Formation 4 Conclusion