生物相容性
抗菌剂
纳米技术
材料科学
自愈水凝胶
再生(生物学)
化学
有机化学
冶金
生物
高分子化学
细胞生物学
作者
Yue Li,Yong Miao,Lunan Yang,Yitao Zhao,Keke Wu,Zhihui Lu,Zhiqi Hu,Jinshan Guo
标识
DOI:10.1002/advs.202202684
摘要
Due to the abuse of antibiotics and the emergence of multidrug resistant microorganisms, medical devices, and related biomaterials are at high risk of microbial infection during use, placing a heavy burden on patients and healthcare systems. Metal-phenolic networks (MPNs), an emerging organic-inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti-inflammatory, antioxidant, and antibacterial properties by making use of the coordination between phenolic ligands and metal ions. Further, MPNs have received widespread attention in antimicrobial infections due to their facile synthesis process, excellent biocompatibility, and excellent antimicrobial properties brought about by polyphenols and metal ions. In this review, different categories of biomaterials based on MPNs (nanoparticles, coatings, capsules, hydrogels) and their fabrication strategies are summarized, and recent research advances in their antimicrobial applications in biomedical fields (e.g., skin repair, bone regeneration, medical devices, etc.) are highlighted.
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