Facile one-pot three-component strategy for the synthesis of 2-amino-4-arylthiazoles via elemental sulfur source

A novel and facile metal-free method for the green synthesis of 2-amino-4-arylthiazole derivatives through the three-component cascade reaction of aromatic methyl ketones, elemental sulfur and cyanamide is reported. One CN bond and two CS bonds were formed in one-pot protocol without using catalysts.