Plasma Rivaroxaban Level in Patients With Early Stages of Chronic Kidney Disease—Relationships With Renal Function and Clinical Events

拜瑞妥 医学 肾功能 肾脏疾病 内科学 胃肠病学 槽水位 心房颤动 槽浓度 华法林 药代动力学 移植 他克莫司
作者
Chun-fung Sin,Ka-ping Wong,Hoi-Ching Wong,Chung‐Wah Siu,Desmond Y. H. Yap
出处
期刊:Frontiers in Pharmacology [Frontiers Media]
卷期号:13 被引量:13
标识
DOI:10.3389/fphar.2022.888660
摘要

Introduction Drug accumulation of rivaroxaban is a concern in patients with chronic kidney disease (CKD). Data regarding the plasma rivaroxaban levels in early CKD patients and its relationship with clinical events is lacking. Methods Early CKD patients (Stage 1-3) with atrial fibrillation who received rivaroxaban (15 or 20 mg daily) were recruited. Plasma rivaroxaban levels were measured at 2 hours (peak) and 24 hours (trough) after drug administration, and correlated with eGFR and clinically significant events during the follow-up period (1 January 2018 to 31 October 2021). Results Ninety-two patients were included (CKD stage 1 n=10, stage 2 n=53, stage 3 n=29). Plasma trough levels in patients with stage 3 CKD were significantly higher than those with stage 2 and 1 CKD (66.0±34.9 ng/ml vs. 35.7 ± 24.7 ng/ml vs. 34.7 ± 26.2 ng/ml, respectively, p=0.005), and showed inverse relationship with eGFR (r=0.391, p=0.001) in patients receiving 20 mg daily. The plasma trough rivaroxaban level correlated with PT and APTT (r = 0.650 and 0.44, respectively, p<0.001 for both). Plasma trough rivaroxaban level in those with bleeding were higher than those who did not (59.9 ± 35.6 ng/ml vs. 41.1 ± 29.2 ng/ml, p=0.011), and multivariate analysis suggested that plasma trough rivaroxaban level was associated with the rate of bleeding complications (OR: 1.020, 95% CI 1.002-1.038, p=0.028). Conclusion Plasma trough rivaroxaban levels correlated with renal function in early CKD patients, and its measurement may help dosage optimization in patients with renal impairment. Moreover, our data suggests that there may be an association between plasma trough rivaroxaban level and the rate of bleeding complication.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Vivian应助大力采纳,获得10
1秒前
酸梅完成签到,获得积分10
1秒前
2秒前
2秒前
ColinWine发布了新的文献求助10
3秒前
不耗蓝完成签到,获得积分10
5秒前
6秒前
7秒前
鲜于元龙发布了新的文献求助10
7秒前
搬运工完成签到,获得积分10
8秒前
00111100完成签到,获得积分20
9秒前
9秒前
9秒前
哈哈哈哈完成签到,获得积分10
10秒前
不耗蓝发布了新的文献求助10
11秒前
脑洞疼应助Han采纳,获得10
11秒前
搬运工发布了新的文献求助10
12秒前
13秒前
14秒前
李健的小迷弟应助凛玖niro采纳,获得10
14秒前
15秒前
小蒋发布了新的文献求助10
15秒前
15秒前
zz发布了新的文献求助10
16秒前
16秒前
suuuu发布了新的文献求助10
16秒前
科研通AI5应助于安采纳,获得10
16秒前
laber应助whl采纳,获得30
17秒前
书笙完成签到,获得积分10
17秒前
武雨寒发布了新的文献求助10
17秒前
Bystander完成签到 ,获得积分10
20秒前
XXJ发布了新的文献求助10
20秒前
daytek发布了新的文献求助10
21秒前
称心涵柳发布了新的文献求助10
21秒前
22秒前
Ling发布了新的文献求助10
23秒前
英姑应助zxt采纳,获得30
23秒前
23秒前
Han发布了新的文献求助10
26秒前
隐形曼青应助zz采纳,获得10
27秒前
高分求助中
Technologies supporting mass customization of apparel: A pilot project 600
Introduction to Strong Mixing Conditions Volumes 1-3 500
Tip60 complex regulates eggshell formation and oviposition in the white-backed planthopper, providing effective targets for pest control 400
A Field Guide to the Amphibians and Reptiles of Madagascar - Frank Glaw and Miguel Vences - 3rd Edition 400
Optical and electric properties of monocrystalline synthetic diamond irradiated by neutrons 320
共融服務學習指南 300
Essentials of Pharmacoeconomics: Health Economics and Outcomes Research 3rd Edition. by Karen Rascati 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3800578
求助须知:如何正确求助?哪些是违规求助? 3345726
关于积分的说明 10327235
捐赠科研通 3062303
什么是DOI,文献DOI怎么找? 1680951
邀请新用户注册赠送积分活动 807284
科研通“疑难数据库(出版商)”最低求助积分说明 763614