宫颈癌
医学
机制(生物学)
癌症
作用机理
传统医学
肿瘤科
生物信息学
药理学
内科学
生物
哲学
生物化学
认识论
体外
作者
Kai Qian,Dan Fu,Baorui Jiang,Yue Wang,Fei Tian,Song Li,Lei Li
标识
DOI:10.3389/fphar.2021.808144
摘要
Cervical cancer is one of the most common malignant tumors among women in the world. In clinical practice, Hedyotis diffusa has pharmacological effects in treating cervical cancer, but its components are relatively complex, and the mechanism of Hedyotis diffusa in treating cervical cancer is still unclear. In this work, the potential active components and mechanism of Hedyotis diffusa in the treatment of cervical cancer were explored by means of network pharmacology. By constructing its active ingredient-target network, and enriching and analyzing the targets, we found the key targets and their effective components (beta-Sitosterol and Quercetin) that play a therapeutic role. Finally, we evaluated the prognostic value of the core target genes through survival analysis. Our work initially explored the therapeutic mechanism of cervical cancer, which lays a theoretical foundation for further exploring its pharmacological action and its clinical application.
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