神经毒性
吸入
吸入染毒
毒性
沉积(地质)
聚苯乙烯
纳米颗粒
环境化学
生物物理学
化学
纳米技术
材料科学
药理学
解剖
生物
有机化学
聚合物
古生物学
沉积物
作者
Xiaoyan Liu,Yingcan Zhao,Jiabin Dou,Qinghong Hou,Jinxiong Cheng,Xingyu Jiang
出处
期刊:Nano Letters
[American Chemical Society]
日期:2022-01-28
卷期号:22 (3): 1091-1099
被引量:64
标识
DOI:10.1021/acs.nanolett.1c04184
摘要
The potential toxicity of nanoplastics on plants has previously been illustrated, but whether nanoplastics could cause neurotoxicity, especially to higher animals, remains unclear. We now demonstrate that nanoplastics can be deposited in the brain via nasal inhalation, triggering neuron toxicity and altering the animal behavior. Polystyrene nanoparticles (PS-NPs) of PS-COOH and PS-NH2 are used as models for nanoplastics. We designed a microfluidic chip to evaluate the PS-NPs with different concentrations, surface ligands, and sizes to interact with neurons. Smaller PS-NPs can induce more cellular uptake than larger PS-NPs. PS-NPs with a size of 80 nm can reach and deposit in the brain of mice via aerosol inhalation. Mice inhaling PS-NPs exhibit fewer activities in comparison to those inhaling water droplets. An obvious neurotoxicity of the nanoplastics could be observed from the results of the inhibition of AChE activities. Our results show the potential significance of the physiochemical properties of organic nanoplastics on depositing in mammalian brains by nasal inhalation.
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