钠通道
钠通道阻滞剂
神经科学
医学
离子通道
慢性疼痛
药理学
生物信息学
生物
化学
受体
内科学
钠
有机化学
作者
Phuong T. Nguyen,Vladimir Yarov-Yarovoy
标识
DOI:10.3389/fphar.2022.842032
摘要
Voltage-gated sodium (NaV) channels are critical molecular determinants of action potential generation and propagation in excitable cells. Normal NaV channel function disruption can affect physiological neuronal signaling and lead to increased sensitivity to pain, congenital indifference to pain, uncoordinated movement, seizures, or paralysis. Human genetic studies have identified human NaV1.7 (hNaV1.7), hNaV1.8, and hNaV1.9 channel subtypes as crucial players in pain signaling. The premise that subtype selective NaV inhibitors can reduce pain has been reinforced through intensive target validation and therapeutic development efforts. However, an ideal therapeutic has yet to emerge. This review is focused on recent progress, current challenges, and future opportunities to develop NaV channel targeting small molecules and peptides as non-addictive therapeutics to treat pain.
科研通智能强力驱动
Strongly Powered by AbleSci AI