A synthetic study of magallanesine by cyclization of a benzamidoacrylate intermediate

Cyclization of a benzamidoacrylate intermediate has been applied for the synthesis of magallanesine rings. Heck reaction for the five-membered ring and the following Friedel–Crafts reaction provided the azocine central rings of the alkaloid. The precursor obtained by cyclizations from a properly functionalized benzamidoacrylate has been converted successfully to magallanesine via the final oxidation with DDQ.