罗伊乳杆菌
益生菌
厚壁菌
拟杆菌
免疫系统
肠道菌群
乳酸菌
微生物学
生物
肿瘤坏死因子α
粪便
双歧杆菌
免疫学
细菌
遗传学
16S核糖体RNA
作者
Jianzhong He,Wenwen Wang,Zhen Wu,Daodong Pan,Zhendong Cai,Liwei Lian
标识
DOI:10.1016/j.jff.2018.12.010
摘要
Probiotic candidate Lactobacillus reuteri DMSZ 8533 was screened out in vitro based on a relatively higher gastrointestinal tolerance and moderate adhesiveness. The organ index (spleen, thymus and liver), Interleukin-12 (IL-12), tumor necrosis factor-α (TNF-α), T-lymphocytes (CD3-, CD4- and CD-8 positive cells) and fecal microbiota composition were also investigated in BALB/c mice. Results showed a significant higher level of IL-12 at low-dose L. reuteri treated group in both females and males. The relative abundance of phylotypes in the phylum Bacteroidetes and Firmicutes exhibited a reserve shift between sexes after L. reuteri intervention. Meanwhile, the relative abundance of several taxa also differed markedly between sexes at low-dose group, together with microbiota diversity. Our finding demonstrates the importance of L. reuteri DMSZ 8533 as a potential probiotic strain with an immunomodulatory effect, which could also alter the microbiota composition depending on the sex of the host.
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