PO-0831 Effect of pre-treatment hematological indices on survival in cervical cancer

Purpose or ObjectiveThe movements of utero-cervical complex, variation in organ filling (rectal and bladder), tumor regression and set-up uncertainties during the course of radiation pose a major challenge for the use of conformal radiation techniques in the treatment of cervical cancers.This prospective, observational study aimed to assess of set-up margins and further sub-site anisotropic margin expansions by quantifying set-up errors and organ motion, respectively in cervical cancer image-guided radiation therapy (IGRT). Material and MethodsPatients with locally advanced cervical cancer undergoing definitive pelvic radio (chemo) therapy between April 2011 and April 2017 were included.Daily pre-treatment 3D-volumetric kilo-voltage, cone-beam computed tomography (kV-CBCT) of pelvic region was acquired.Initially co-registration of daily CBCT with the planning CT images was done to match pelvic vessels/CTV pelvic nodal region after initial rigid alignment based on bony anatomy.Subsequently, soft-tissue matching was done to record the residual set-up errors to assess organ motion at the levels of mid-cervical canal and uterine fundus, separately (Figure 1).