吞咽困难
德尔菲法
医学
头颈部癌
临床试验
吞咽
德尔菲
物理疗法
家庭医学
生活质量(医疗保健)
患者报告的结果
医学物理学
外科
放射治疗
护理部
内科学
人工智能
计算机科学
操作系统
作者
Beatrice Manduchi,Margaret Fitch,Jolie Ringash,Doris Howell,Rosemary Martino
出处
期刊:Head & neck
[Wiley]
日期:2024-01-10
卷期号:46 (4): 831-848
摘要
Measuring dysphagia-related patient-reported outcomes (PROs) in Head and Neck Cancer (HNC) patients is challenging due to dysphagia's multidimensional impact, causing inconsistency in outcome reporting. To address this issue, this study derived a consensus-based core outcome set (COS) for patient-reported dysphagia in HNC clinical trials where swallowing is a primary or secondary endpoint.A sample of HNC clinicians, researchers, patients, and caregivers participated in a 2-Round Delphi technique. A Delphi survey, containing a comprehensive list of dysphagia-related PROs, was developed. In Round 1, participants rated item importance on a 5-point scale. Items rated ≥4 by >70% advanced to Round 2, where a consensus meeting addressed items with varied opinions, and the Delphi survey with remaining items was completed. Items rated ≥4 by >70% formed the final COS.Forty-five participants from nine countries were recruited. After Round 1, 40 items were excluded and 64 advanced to Round 2. After Round 2, a 7-outcome COS was established, comprising the domains of dysphagia symptoms, health status and quality of life.This study achieved consensus among HNC stakeholders on essential dysphagia PROs for HNC clinical trials. It is advisable to include these 7-core concepts in clinical trials involving people with HNC to facilitate treatment comparisons and data synthesis.
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