封装(网络)
纳米技术
自愈水凝胶
材料科学
药物输送
计算机科学
高分子化学
计算机网络
作者
Valentina Andretto,Annalisa Rosso,Serena Zilio,Jacqueline Sidi‐Boumedine,Gilles Boschetti,Sharanya Sankar,Marie Buffier,A.E. Miele,Morgane Denis,Pierre‐Antoine Choffour,Stéphanie Briançon,Stéphane Nancey,David Kryza,Giovanna Lollo
标识
DOI:10.1002/adhm.202303280
摘要
Abstract Conventional therapies for inflammatory bowel diseases are mainly based on systemic treatments which cause side effects and toxicity over long‐term administration. Nanoparticles appear as a valid alternative to allow a preferential accumulation in inflamed tissues following oral administration while reducing systemic drug exposure. To increase the residence time of nanoparticles in the inflamed intestine, a hybrid nanocomposite with customized properties is here developed by associating them with a hydrogel matrix. A bioadhesive peptide‐based hydrogel is mixed with nanoemulsions, creating a hybrid lipid‐polymer nanocomposite. Mucopenetrating nanoemulsions of 100 nm are embedded in a scaffold constituted of the self‐assembling peptide hydrogel product PuraStat ® . The nanocomposite is fully characterized to study the impact of lipid particles in the hydrogel structure. Rheological measurements and circular dichroism analyses are performed to investigate the system's microstructure and physical properties. Biodistribution studies demonstrate that the nanocomposite acts as a depot in the stomach and facilitates the slow release of the nanoemulsions in the intestine. Efficacy studies upon oral administration of the drug‐loaded system show the improvement of the disease score in a mouse model of intestinal inflammation. This article is protected by copyright. All rights reserved
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