来曲唑
卵巢过度刺激综合征
医学
妊娠率
卵母细胞
妇科
不育
安慰剂
怀孕
辅助生殖技术
控制性卵巢过度刺激
男科
体外受精
内科学
生物
胚胎
芳香化酶
病理
替代医学
乳腺癌
癌症
细胞生物学
遗传学
作者
Batool Hossein Rashidi,Ensieh Shahrokh Tehraninejad,Saeid Amanpour,Fatemeh Bandarian,Mahin Bandarian
标识
DOI:10.1080/09513590.2022.2160869
摘要
Objective To examine the effect of letrozole on oocyte quality and pregnancy outcome in assisted reproductive technology (ART).Methods This double blind placebo controlled clinical trial was conducted in Vali-Asr Infertility Center. Infertile women candidate for IVF that underwent antagonist protocol were selected. Eligible women randomly allocated into treatment (letrozole/Let group) and control (placebo) group. Participants received letrozole 5 mg/day or placebo at the time of gonadotropin start until trigger day in the same manner. Number of oocyte retrieved, metaphase II oocyte number, high grade oocyte number (G1), high quality embryo, Chemical and clinical pregnancy rate and OHSS (ovarian hyperstimulation syndrome) rate was recorded. 216 infertile women (104 in letrozole and 112 in the control group) were evaluated.Results In the Let group estradiol level was significantly lower (p_value < .001) and testosterone significantly higher than in the control group (p_value = .02). The number of retrieved oocytes, MII oocytes, G1 oocytes, and 2PN was significantly lower in the Let group (p < .05). No significant difference was found in the day of stimulation, total gonadotropin dose, OHSS rate, and clinical pregnancy rate between the two groups (p > 0.05).Conclusions According to the results, letrozole may reduce oocyte quality and cause poor IVF outcomes as well.
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