Synthesis and application of quantum dots in detection of environmental contaminants in food: A comprehensive review

Environmental pollutants can accumulate in the human body through the food chain, which may seriously impact human health. Therefore, it is of vital importance to develop quick, simple, accurate and sensitive (respond quickly) technologies to evaluate the concentration of environmental pollutants in food. Quantum dots (QDs)-based fluorescence detection methods have great potential to overcome the shortcomings of traditional detection methods, such as long detection time, cumbersome detection procedures, and low sensitivity. This paper reviews the types and synthesis methods of QDs with a focus on green synthesis and the research progress on rapid detection of environmental pollutants (e.g., heavy metals, pesticides, and antibiotics) in food. Metal-based QDs, carbon-based QDs, and "top-down" and "bottom-up" synthesis methods are discussed in detail. In addition, research progress of QDs in detecting different environmental pollutants in food is discussed, especially, the practical application of these methods is analyzed. Finally, current challenges and future research directions of QDs-based detection technologies are critically discussed. Hydrothermal synthesis of carbon-based QDs with low toxicity from natural materials has a promising future. Research is needed on green synthesis of QDs, direct detection without pre-processing, and simultaneous detection of multiple contaminants. Finally, how to keep the mobile sensor stable, sensitive and easy to store is a hot topic in the future.