Glucose oxidase-powered nanocatalytic medicine: Rewiring tumor metabolism for multimodal cancer therapy

concentration, and oxygen tension - creates favorable conditions for combination therapies. This catalytic synergy enhances the efficacy of diverse treatment modalities including chemotherapy, chemodynamic therapy, photodynamic therapy, photothermal therapy, gas therapy, and immunotherapy. This review comprehensively examines recent progress in GOX-based nanocatalytic platforms, focusing on their design principles, therapeutic mechanisms, and potential for multimodal cancer treatment.