Multiplex Graph Guided Deep Survival Analysis

Survival analysis is extensively employed to analyze the probability of the event of interest, particularly in the medical field. Most current research treats patients as isolated entities, neglecting the complex associations among them, which leads to underutilization of valuable information. Recently, several studies address this limitation by incorporating patient graph structures. However, these approaches generally overlook two critical issues: 1) the exploration of heterogeneous inter-patient relationships, and 2) flexible and scalable inductive inference for test samples. To overcome these challenges, this study introduces a novel framework, Multiplex Graph Guided Deep Survival Analysis (MGG-Surv). Specifically, we employ multiplex patient graphs to capture comprehensive inter-patient associative information. Furthermore, we propose a teacher-student dual network architecture, where the teacher network encodes multiplex graphs, and the learned graph knowledge is transferred to the student network via a unidirectional connection termed Graph-Guided Distillation. The student network integrates this graph knowledge to predict survival outcomes without requiring the patient graphs. These innovative designs facilitate comprehensive integration of inter-patient relationships while achieving flexible and scalable graph-free inference. Experiments on four datasets, encompass-ing both single and competing risks, demonstrate the superior performance of our framework.