Drug-induced liver injury (DILI) refers to a type of liver dysfunction induced by various drugs or their metabolites, which can be life-threatening. Its incidence is increasing gradually, and it has become a non-negligible global health burden. In daily life, many common medications can lead to DILI. However, there is still no single indicator which is specific for the diagnosis of DILI, and the medications for the treatment of DILI are clinically diverse. In addition, pharmacological therapy also faces additional challenges in some special populations with DILI, such as elderly people, children, and pregnant women. This chapter aims to summarize the current overview of various drugs to treat DILI in clinical practice.